Protective Effects of Baicalin on Experimental Myocardial Infarction in Rats

This study aimed to investigate the protective effects of baicalin on myocardial infarction in rats and explore the related mechanisms.Methods: Fifty Sprague Dawley rats were randomly divided into the control, model, and low-, medium- and high-dose baicalin groups. The latter 3 groups were intraperitoneally injected with baicalin, with a dose of 12.5, 25 and 50 mg/kg, respectively. Then, the myocardial infarction model was established. The hemodynamic of rats was tested, the serum lactate dehydrogenase (LDH), creatine kinase-MB (CK-MB), prostacyclin (PGI2) and thromboxane A2 (TXA2) were determined, the myocardial ...
Source: Brazilian Journal of Cardiovascular Surgery - Category: Cardiology Source Type: research