Glucocorticoid interactions with the dorsal striatal endocannabinoid system in regulating inhibitory avoidance memory

The endocannabinoid (eCB) system, mainly through activity-dependent retrograde actions of the endogenous ligands anandamide and 2-arachidonoylglycerol on cannabinoid type 1 receptors (CB1Rs), controls the firing rate of both excitatory and inhibitory neurons, which is vital for neural communication and plasticity changes (Di Marzo et al., 1998; Gray et al., 2014; Lovinger and Mathur, 2017; Ohno-Shosaku and Kano, 2014). The eCB system is highly sensitive to stress and emerged as a key modulator of the stress response, emotion regulation and emotional memory (Balsevich et al., 2017; Hill et al., 2010b; Lutz et al., 2015; Morena et al., 2016).

Source: Psychoneuroendocrinology - August 30, 2018 Category: Psychiatry Authors: Cristina Siller-P érez, Antonio Fuentes-Ibañez, Erika L. Sotelo-Barrera, Norma Serafín, Roberto A. Prado-Alcalá, Patrizia Campolongo, Benno Roozendaal, Gina L. Quirarte Source Type: research