Atypical Femoral Fracture Associated With Overuse of Bisphosphonate Evaluated by High-Resolution Peripheral Quantitative Computed Tomography (HR-pQCT): A Case Report

Atypical femoral fracture (AFF) is defined as an atraumatic fracture on the subtrochanteric region or femoral shaft (1, 2). A population-based study in Canada reported the incidence of AFF to be 7.0 (ranging from 4.7 to 9.3) cases per 100,000 person-years (3). AFF is a rare side effect of the long-term use of bisphosphonates (4), which may attribute to severe suppression of bone turnover (5). The relative risk of AFF with bisphosphonate use was 47.3% (6). The average duration of bisphosphonate use in causing AFF is 5 yr, ranging from 3 mo to 16 yr (7).

Source: Journal of Clinical Densitometry - August 29, 2018 Category: Radiology Authors: Lijia Cui, Yuping Xu, Qiming Xu, Yan Jiang, Ou Wang, Mei Li, Xiaoping Xing, Weibo Xia Tags: Case Report Source Type: research