Wysokie dawki cyklofosfamidu po niemieloablacyjnym haploidentycznym przeszczepieniu komórek krwiotwórczych u dziecka z nawrotową postacią nerwiaka zarodkowego: krok w kierunku rozdzielenia reakcji GVT i GVH

The objective of this report is an analysis of case of a child treated for relapsed neuroblastoma with haploidentical HSCT with PTCy. In this case following therapeutic modalities were combined: haploidentical HSCT in pediatric solid tumor relapsing after autologous HSCT, non-myeloablative haploidentical HSCT with unmanipulated T-repleted graft, and post-transplant use of high-dose cyclophosphamide as GVHD prophylaxis. This strategy was safe and efficient, as we observed low toxicity, relatively fast hematological engraftment, and hyperacute GVHD followed by mild GVHD. Patient stayed in remission for 12 months. Based on published data, it seems possible, that PTCy selectively depletes T cells that react against host allo-antigens, yet preserves tumor-specific and pathogen reactive T cells.
Source: Acta Haematologica Polonica - Category: Hematology Source Type: research