Recent advances of the Povarov reaction in medicinal chemistry

Publication date: Available online 28 August 2018Source: Drug Discovery Today: TechnologiesAuthor(s): Ouldouz Ghashghaei, Carme Masdeu, Concepción Alonso, Francisco Palacios, Rodolfo LavillaThe Povarov multicomponent reaction consists on the condensation of an aniline, an aldehyde, and an activated olefin to generate a tetrahydroquinoline adduct with 3 diversity points. Hereby, we report the main features of this transformation and its uses in medicinal chemistry. Relevant examples of the impact of Povarov adducts in different therapeutic areas are provided.Graphical abstract
Source: Drug Discovery Today: Technologies - Category: Drugs & Pharmacology Source Type: research