Xanthotoxin induces apoptosis in SGC-7901 cells through death receptor pathway

ConclusionXanthotoxin may induce SGC-7901 cells apoptosis in a certain concentration range through the Fas/FasL protein mediated death receptor pathway, or by DR5/TRAIL mediated death receptor pathway, and increase the expression level of death receptor protein, activation Caspase-8, activating downstream effect factor, inducing cell apoptosis, or activate Caspase-8 cutting activate protein Bid, and then enter the mitochondrial pathway, induction of apoptosis.
Source: Chinese Herbal Medicines - Category: Complementary Medicine Source Type: research