Revisiting the Dynamic Cancer Stem Cell Model: Importance of Tumour Edges

The lack of an effective treatment against cancer is not only due to its huge heterogeneity, but also to the fact that we don ’t have an answer to the question on how cancer originates. Among the proposed models to explain the development of cancer, the hierarchical model has been widely accepted. Nevertheless, this model fails to explain several experimental observations such as the cancer stem cells (CSCs) location ins ide a tumour or the differences between primary and metastatic tumours. Moreover, increasing evidence shows that the CSC phenotype is not a rigid state.
Source: Critical Reviews in Oncology Hematology - Category: Cancer & Oncology Authors: Source Type: research