Analysis of early phase and subsequent phase III stroke studies of neuroprotectants: outcomes and predictors for success

Conclusions More than one third of early phase studies on neuroprotective stroke treatments are false positive. Neither the results nor specific study design characteristics of early phase stroke studies reliably predict success in phase III trials. Further efforts are needed to improve early phase studies regarding its predictability and to identify those early studies that should be advanced to phase III trials.
Source: Experimental and Translational Stroke Medicine - Category: Neurology Source Type: research