Postnatal impoverished housing impairs adolescent risk-assessment and increases risk-taking: a sex-specific effect associated with histone epigenetic regulation of Crfr1 in the medial prefrontal cortex

There is considerable evidence showing that early-life stress (ELS) exposure can negatively affect brain development, producing an array of clinically relevant behavioral and cognitive alterations (Blair and Raver, 2016; Harrison and Baune, 2014). These consequences may prime such vulnerable individuals toward the development of neuropsychiatric illnesses during adolescence as well as young adulthood (Grassi-Oliveira et al., 2008). While increasing evidence posits poor decision-making as a central feature of mental disorders (Kluwe-Schiavon et al., 2016b; Steward et al., 2016), very few studies investigated the effects of ELS on specific cognitive components of choice behaviors.

Source: Psychoneuroendocrinology - August 26, 2018 Category: Psychiatry Authors: Thiago Wendt Viola, Luis Eduardo Wearick-Silva, Kerstin C. Creutzberg, Érika Kestering, Rodrigo Orso, Anderson Centeno-Silva, Lucas Albrechet-Souza, Paul R. Marshall, Xiang Li, Timothy W. Bredy, Marco A. Riva, Rodrigo Grassi-Oliveira Source Type: research