The study of GPX3 methylation in patients with Kashin-Beck Disease and its mechanism in chondrocyte apoptosis

Selenium deficiency is a risk factor for Kashin-Beck Disease (KBD), an endemic osteoarthropathy. Although promoter hypermethylation of glutathione peroxidase 3 (GPX3) (a selenoprotein) has been identified in several cancers, little is known about promoter methylation and expression of GPX3 and their relation to selenium in KBD. The present study was thus conducted to investigate this research question.

Source: Bone - August 25, 2018 Category: Orthopaedics Authors: Lixin Han, Xiaoli Yang, Wenyan Sun, Zhaofang Li, Hao Ren, Baorong Li, Rongqiang Zhang, Dandan Zhang, Ziyun Shi, Jifeng Liu, Junling Cao, Jianjun Zhang, Yongmin Xiong Tags: Full Length Article Source Type: research