Author Response to: Modulating Kynurenine Monooxygenase in Microglia: the need for further characterization

In their letter to the editor, Mr. Moon and Mr. Minhas make several points that are entirely consistent with the original text of our manuscript (Garrison et al., 2018). Unfortunately, they present them as points of criticism instead of agreement. Namely, our study described a novel observation that inhibition of kynurenine monooxygenase (KMO), but not indoleamine 2,3-dioxygenase (IDO), in mouse microglia attenuated several LPS-induced responses, including upregulation of TNF-alpha transcripts and accumulation of nitrite.

Source: Psychoneuroendocrinology - August 24, 2018 Category: Psychiatry Authors: Allison M. Garrison, Jennifer M. Parrott, Arnulfo Tunon, Jennifer Delgado, Laney Redus, Jason C. O ’Connor Source Type: research