LmrP from Lactoccoccus lactis: a tractable model to understand secondary multidrug transport in MFS

Publication date: Available online 23 August 2018Source: Research in MicrobiologyAuthor(s): Aurélie Roth, Cedric GovaertsAbstractThe secondary transporter LmrP from L. lactis is a remarkable model to study the molecular basis of secondary multidrug transport. This review article addresses more than twenty years of research about transport activity, substrates range, conformational dynamics and mechanistic models of drug export for LmrP. Several studies have shown that the transporter alternates between inward-open and outward-open conformations and that the transition is regulated by the protonation state of key acidic residues and is further modulated by the lipid environment.
Source: Research in Microbiology - Category: Microbiology Source Type: research