Inhibition of activated astrocyte ameliorates lipopolysaccharide- induced depressive-like behaviors

Major depressive disorder (MDD) is a complex mood disorder estimated to affect millions of people, and a leading cause of disability and mortality worldwide (Harrison et al., 2018). Depression and neurodegenerative diseases such as Alzheimer's disease, Parkinson's diseases are common comorbid conditions. It is also an potent indication of latent neurodegeneration (Hurley and Tizabi, 2013). Based on the widely recognized monoaminergic hypothesis, serotonin selective reuptake inhibitors (SSRIs) and serotonin and noradrenaline selective reuptake inhibitors (SNRIs) became the mainstream pharmacological treatments for depression patients.
Source: Journal of Affective Disorders - Category: Neurology Authors: Source Type: research