Improvement of the resistance against early Mycobacterium tuberculosis-infection in the absence of PI3K γ enzyme is associated with increase of CD4+IL-17+ cells and neutrophils
Given the impossibility to study the lung immune response during Mycobacterium tuberculosis-latent infection, and consequently, the mechanisms that control the bacterial load, it is reasonable to determine the activation of local immunity in the early phase of the infection. The phosphatidylinositol-3-kinase gamma enzyme (PI3K γ) is involved in the leukocyte recruitment, phagocytosis and cellular differentiation, and therefore, it is considered a promising target for the development of immunotherapies for chronic inflammatory diseases.
Source: Tuberculosis - Category: Respiratory Medicine Authors: M.P. Cavalcanti-Neto, R.Q. Prado, A.R. Pi ñeros, C.A. Sérgio, T.B. Bertolini, A.F. Gembre, S.G. Ramos, V.L. Bonato Tags: Immunological Aspects Source Type: research