BCG constitutively expressing the adenylyl cyclase encoded by Rv2212 increases its immunogenicity and reduces replication of M. tuberculosis in lungs of BALB/c mice

Mycobacterium tuberculosis remains as a threat to public health around the world with 1.7 million cases of TB-associated deaths during 2016. Despite the use of Bacillus Calmette-Guerin (BCG) vaccine, control of the infection has not been successful. Because of this, several efforts have been made in order to develop new vaccines capable of boosting or attempted for replacing current BCG. We previously showed that over expression of the M. tuberculosis adenylyl cyclase encoding gene Rv2212 in BCG bacilli (BCG-Rv2212), induced an attenuated phenotype when administered in BALB/c mice.

Source: Tuberculosis - August 23, 2018 Category: Respiratory Medicine Authors: C ésar Pedroza-Roldán, Brenda Marquina-Castillo, Dulce Mata-Espinosa, Jorge Barrios-Payán, Michel de Jesús Aceves-Sánchez, Rogelio Hernández Pando, Mario Alberto Flores-Valdez Tags: Model Systems Source Type: research