Activator of mitochondrial aldehyde dehydrogenase (Alda-1) could enhance quality of equine cooled semen by ameliorating loss of mitochondrial function over time

Equine sperm energy metabolism is mainly dependent on mitochondrial oxidative phosphorylation, causing abundant production of reactive oxygen species (ROS). Reacting with fatty acids, ROS result in formation of aldehydes, which diminish sperm viability and motility. Aldehyde dehydrogenases are responsible for removal of aldehydes. Alda-1 is the activator of mitochondrial aldehyde dehydrogenase and has been shown to alleviate the detrimental effects of aldehydes in different tissues. The present study was conducted to evaluate the influence of Alda-1 on cooled stallion semen over a 72-hour period.
Source: Journal of Equine Veterinary Science - Category: Veterinary Research Authors: Tags: Original Research Source Type: research