B-type natriuretic peptide prevents postnatal closure of ductus arteriosus by both vasodilation and anti-remodeling in neonatal rats

In conclusion, BNP prevents postnatal DA closure by both vasodilation and anti-remodeling through the cGMP pathway. The mechanisms underlying anti-remodeling effects include anti-proliferation and anti-migration, with attenuation of mitochondrial ROS production and intracellular calcium and ERK1/2 signaling. Therefore, the BNP/cGMP pathway can be a promising therapeutic target for clinical management of DA patency.

Source: Clinical Science - August 17, 2018 Category: Biomedical Science Authors: Yeh, J.-L., Wu, J.-R., Wu, B.-N., Yang, S.-F., Dai, Z.-K., Liou, S.-F., Hsu, J.-H. Tags: PublishAheadOfPrint Source Type: research