Lymph node yield as a predictor of overall survival following inguinal lymphadenectomy for penile cancer

Penile cancer is rare in the United States (US) with an incidence of 0.58/100,000 [1]. The majority of cases are squamous cell carcinoma. Management of penile squamous cell carcinoma (pSCC) is based on local invasiveness of the tumor, tumor grade, and staging of regional (inguinal and pelvic) lymph nodes (LNs) [2]. Involvement of the regional LNs is an adverse pathological finding and has been demonstrated to influence cancer-specific survival (CSS) and overall survival (OS) [3]. Inguinal lymphadenectomy (ILND) is, therefore, an important part of the treatment algorithm for clinically node positive disease (cN+) [4].
Source: Urologic Oncology: Seminars and Original Investigations - Category: Urology & Nephrology Authors: Tags: Original article Source Type: research