Identification and characterization of a novel HLA‐A allele, HLA‐A*68:105, by genomic sequencing

Summary
A novel HLA‐A allele, HLA‐A*68:105, was detected by sequence‐based typing (SBT) in an Italian bone marrow donor. It differs from HLA‐A*68:01:02 at five nucleotides, three intronic, nt 699 T‐>G (intron 2), nt 705 T‐>C (intron 2) and nt 2770 G‐>A (intron 7), and two located in exon 3, at positions 726 A‐G (codon 94 Ile‐>Val) and 733 T‐G (codon 97 Arg‐>Met), respectively.

Source: International Journal of Immunogenetics - October 1, 2014 Category: Genetics & Stem Cells Authors: M. Curcio, S. Presciuttini, R. Sciarrino, S. Fornaciari, M. L. Mariotti, F. Scatena Tags: Short Communication Source Type: research