Researchers develop mouse model for study of human immunodeficiency disease

NHGRI and NIAID researchers developed a new mouse model of a human immunodeficiency disease caused by mutations to the gene PI3-kinase delta. Treating these mutant mice with broad antibiotics prevented both the hyper-reactivity of their lymphocytes (white blood cells that are part of the immune system) and the generation of a wide range of autoantibodies. The findings, published inNature Immunology, have broad implications for a people with immunodeficiencies and autoimmune conditions.
Source: NHGRI Homepage Highlights - Category: Genetics & Stem Cells Source Type: news