Endothelial Insulin Resistance Protects the Heart Against Prolonged Ischemia-Reperfusion Injury But Does Not Prevent Insulin Transport Across the Endothelium in a Mouse Langendorff Model

Conclusion:
(1) Insulin at pharmacologic concentrations can be transported across the endothelium independent of vascular insulin receptors and (2) vascular insulin resistance and/or endothelial dysfunction are protective against prolonged IR injury in the Langendorff model.

Source: Journal of Cardiovascular Pharmacology and Therapeutics - October 15, 2014 Category: Cardiology Authors: Sharma, V., Kearney, M. T., Davidson, S. M., Yellon, D. M. Tags: Experimental Studies Source Type: research