AKR1C3, a crucial androgenic enzyme in prostate cancer, promotes epithelial-mesenchymal transition and metastasis through activating ERK signaling

AKR1C3, as a crucial androgenic enzyme, facilitates intratumoral androgen biosynthesis and androgen receptor activation in castration-resistant prostate cancer (PCa). The data has shown that AKR1C3 expression is significantly elevated in clinical metastatic PCa specimens, indicating a potential role of AKR1C3 in PCa metastasis.

Source: Urologic Oncology: Seminars and Original Investigations - August 20, 2018 Category: Urology & Nephrology Authors: Bin Wang, Yanan Gu, Ke Hui, Jun Huang, Shan Xu, Shiqi Wu, Lei Li, Jinhai Fan, Xinyang Wang, Jer-Tsong Hsieh, Dalin He, Kaijie Wu Tags: Original article Source Type: research