Divergent associations between ghrelin and neural responsivity to palatable food in hyperphagic and hypophagic depression

Major Depressive Disorder (MDD) is one of the major causes of disability worldwide due to the negative impacts on functioning and re-occurring nature (WHO,  2017). One of the key challenges for the successful treatment of MDD is the highly heterogeneous nature of the disorder. Efforts to distinguish endophenotypes have revealed several pathophysiological mechanisms underlying depression, including HPA axis dysregulation, inflammation, circadian rhythm disturbances and altered reward sensitivity (Dean and Keshavan, 2017; Goldstein et al., in press.; Schmidt et al., 2011).

Source: Journal of Affective Disorders - August 18, 2018 Category: Neurology Authors: Hilal Cerit, Kara Christensen, Priyanka Moondra, Anne Klibanski, Jill M. Goldstein, Laura M. Holsen Tags: Research paper Source Type: research