Osteoblast derived-neurotrophin ‑3 induces cartilage removal proteases and osteoclast-mediated function at injured growth plate in rats

Faulty bony repair causes dysrepair of injured growth plate cartilage and bone growth defects in children; however, the underlying mechanisms are unclear. Recently, we observed the prominent induction of neurotrophin ‑3 (NT-3) and its important roles as an osteogenic and angiogenic factor promoting the bony repair. The current study investigated its roles in regulating injury site remodelling. In a rat tibial growth plate drill-hole injury repair model, NT-3 was expressed prominently in osteoblasts at the inju ry site.

Source: Bone - August 17, 2018 Category: Orthopaedics Authors: Yu-Wen Su, Shek Man Chim, Lin Zhou, Mohammadhossein Hassanshahi, Rosa Chung, Chiaming Fan, Yunmei Song, Bruce K. Foster, Clive A. Prestidge, Yaser Peymanfar, Qian Tang, Lisa M. Butler, Stan Gronthos, Di Chen, Yangli Xie, Lin Chen, Xin-Fu Zhou, Jiake Xu, C Tags: Full Length Article Source Type: research