Interleukin-6 deletion stimulates revascularization and new bone formation following ischemic osteonecrosis in a murine model

Legg-Calv é-Perthes disease (LCPD) is a childhood form of ischemic osteonecrosis of the femoral head which can produce a permanent femoral head deformity and early osteoarthritis. The femoral head deformity results from increased bone resorption and decreased bone formation during repair and remodeling of th e necrotic femoral head. A recent study showed that a pro-inflammatory cytokine, interleukin-6 (IL-6), is significantly elevated in the synovial fluid of patients with LCPD. We hypothesized that IL-6 elevation decreases bone formation during the repair process following ischemic osteonecrosis and th at IL-6 depletion will increase new bone formation.

Source: Bone - August 17, 2018 Category: Orthopaedics Authors: Gen Kuroyanagi, Naga Suresh Adapala, Ryosuke Yamaguchi, Nobuhiro Kamiya, Zhuo Deng, Olumide Aruwajoye, Michael Kutschke, Elena Chen, Chanhee Jo, Yinshi Ren, Harry K.W. Kim Tags: Full Length Article Source Type: research