GSK-3b 50 T/C polymorphism in bipolar disorder and its relationship with clinical phenotypes and treatment response

Variations in the glycogen synthase kinase gene GSK-3b have been implicated in bipolar disorder (BD) (Muneer, 2017). The rs334558 polymorphism located in the promoter region of the GSK-3b gene alters the transcriptional activity of the gene (Kwok et al., 2005). This polymorphism has been associated with grey/white matter integrity in BD (Benedetti et al., 2015). Although a recent meta-analysis did not find an association between the polymorphism and BD risk, it did not assess therapeutic response to lithium (Chen et al., 2014).
Source: Journal of Affective Disorders - Category: Neurology Authors: Tags: Letter to editor Source Type: research