β-Carboline derivatives as novel antivirals for herpes simplex virus

Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) are double-stranded DNA human herpes viruses belonging to the Alphaherpesvirinae. They are transmitted across epithelial mucosal cells as well as through skin lesions. These viruses migrate along axons towards neuronal ganglia, where they persist in a latent state and may reactivate several times during an individual's lifespan. HSV-1 predominantly causes orofacial lesions, whereas HSV-2 mainly infects the genital mucosa [1].
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Source Type: research