Oxylipins in cerebrospinal fluid in clinically isolated syndrome and relapsing remitting multiple sclerosis

In conclusion, this study indicates that 9-HODE and 13-HODE levels are increased in CSF from CIS and RRMS patients compared with healthy controls, but does not support 9-HODE or 13-HODE as prognostic biomarkers of disease activity in patients during follow-up.Graphical abstractA principal component analysis (first principal component t1 vs. the first orthogonal component t2) model showing the discriminant separation between the patients (pat, green filled circles) and the healthy controls (HC, blue filled circles). The red filled circle represents the patient that was identified as a strong outlier with Hotelling´s T2 test and that patient was excluded from further analyses.
Source: Prostaglandins and Other Lipid Mediators - Category: Lipidology Source Type: research