Clinical outcomes with therapies for previously treated recurrent/metastatic head-and-neck squamous cell carcinoma (R/M HNSCC): A systematic literature review

Head and neck squamous cell carcinoma (HNSCC) ranks sixth among the cancers diagnosed worldwide, and is the eighth most common cause of cancer-related death [1]. A substantial proportion (20 –40%) of patients with HNSCC will suffer local and/or regional disease recurrence and distant metastases [2–4]. Treatment efficacy is modest for patients with locally recurrent (or unresectable) and/or metastatic (R/M) HNSCC, and treatment goals are palliative [5]. For a limited number of patien ts with locoregional recurrent disease, salvage surgery and re-irradiation are considered [2].
Source: Oral Oncology - Category: Cancer & Oncology Authors: Tags: Review Source Type: research