Older Age Predicts Biopsy and Radical Prostatectomy Grade Reclassification to Aggressive Prostate Cancer in Men on Active Surveillance

Age at prostate cancer (PCa) diagnosis has been positively associated with PCa-specific mortality, and for men on active surveillance (AS), a higher risk of biopsy grade reclassification (BGR) to Gleason score ≥3+4 (grade group [GG]≥2); however, the association between age and BGR to an aggressive phenotype (Gleason score ≥4+3 [GG≥3]) has not been explored.

Source: The Journal of Urology - August 13, 2018 Category: Urology & Nephrology Authors: Sasha C. Druskin, Mufaddal Mamawala, Jeffrey J. Tosoian, Jonathan I. Epstein, Christian P. Pavlovich, H. Ballentine Carter, Bruce J. Trock Source Type: research