Lithium-associated anterior cingulate neurometabolic profile in euthymic bipolar i disorder: a 1h-mrs study

The neurobiology of bipolar disorder (BD) has not been fully elucidated, although some part of the knowledge about its neurobiology has emerged from studies on lithium's mechanism of action as a first-line mood stabilizer (Yatham et al., 2013). Modern neuroimaging techniques, such as proton magnetic resonance spectroscopy (1H-MRS), allow in vivo measurement of three non-glutamatergic brain metabolites implicated in both the neurobiology of BD and lithium ´s mechanisms of action: N-acetylaspartate (NAA) (a neuronal marker), Myo-Inositol (mI) (a glia cell marker) and Choline (Cho) (a membrane cell marker) (Berridge, 1989; Silverstone and McGrath, 2009; Stork and Renshaw, 2005).

Source: Journal of Affective Disorders - August 10, 2018 Category: Neurology Authors: Marcio Gerhardt Soeiro-de-Souza, Maria Concepcion Garcia Otaduy, Rodrigo Machado-Vieira, Ricardo Alberto Moreno, Fabiano G. Nery, Claudia Leite, Beny Lafer Source Type: research