Microglial markers in the frontal cortex are related to cognitive dysfunctions in major depressive disorder

In response to an increased attention paid to cognitive dysfunctions in major depressive disorder (MDD), numerous recent studies explored the characteristics and clinical significance of impairments in several cognitive domains. In the Sequenced Treatment Alternatives to Relieve Depression (STAR ∗D) study, the majority of patients with MDD reported subjective difficulty with attention and decision making (Sinyor et al., 2010). Moreover, residual cognitive symptoms pose a serious challenge even in euthymic patients (Bora et al., 2013; Hasselbalch et al., 2011; Nierenberg et al., 2010), nec essitating the achievement of cognitive remission (Bortolato et al., 2016).

Source: Journal of Affective Disorders - August 8, 2018 Category: Neurology Authors: Hua Li, Aadi P. Sagar, Szabolcs K éri Tags: Research paper Source Type: research