The Lack of Meaningful Association Between Depression Severity Measures and Neurocognitive Performance

Mild to moderate deficits in neurocognitive functioning are common in major depression (for review see Austin, Mitchell,& Goodwin, 2001; Rock et al., 2014). However, there has been a vexing lack of correlation between measures of depression severity and these neurocognitive deficits that have led to a range of conclusions including that (a) there may not be a consistent association (McClintock et al., 2010), that (b) the association is only evident when considering large numbers of patients across a wide range of depression severity (McDermott& Ebmeier, 2009), or that (c) neurocognitive deficits only occur in a subsample of patients (e.g., see Iverson et al., 2011).

Source: Journal of Affective Disorders - August 8, 2018 Category: Neurology Authors: John G. Keilp, Sean P. Madden, Marianne Gorlyn, Ainsley K. Burke, Maria A. Oquendo, J. John Mann Tags: Research paper Source Type: research