Metabolic signature of squamous cell carcinoma of the head and neck: Consequences of TP53 mutation and therapeutic perspectives

Squamous cell carcinoma of the head and neck (SCCHN) is the sixth most common cancer globally with an estimated incidence of 750,000 cases per year [1]. Whilst tobacco and alcohol consumption are the major risk factors [2], human papillomavirus (HPV) has emerged as a cause of a specific subset of SCCHN [3]. Despite advances in diagnostic and therapeutic strategies, survival outcomes for HPV-negative SCCHN have not improved significantly over the last 20  years, still accounting for nearly 350,000 deaths annually worldwide [1].

Source: Oral Oncology - June 2, 2018 Category: Cancer & Oncology Authors: Mark D. Wilkie, Andrew S. Lau, Nikolina Vlatkovic, Terence M. Jones, Mark T. Boyd Tags: Review Source Type: research