MicroRNA-based classifiers for diagnosis of oral cavity squamous cell carcinoma in tissue and plasma

The worldwide annual incidence of oral squamous cell carcinoma (OSCC) is estimated to be over 300,000 [1]. Over the last 20  years, the prognosis of patients with OSCC has improved; however, 5-year overall survival is still only around 50% when including all stages and anatomic sub-sites [2]. In early-stage OSCC (clinical T1-T2N0M0), the strongest prognostic risk factor for survival is the presence of occult lymph node metastases, which are detectable by histopathological examination in up to 30–40% of these patients [3–5].

Source: Oral Oncology - June 12, 2018 Category: Cancer & Oncology Authors: Nicklas Juel Pedersen, David Hebbelstrup Jensen, Giedrius Lelkaitis, Katalin Kiss, Birgitte Wittenborg Charabi, Henrik Ullum, Lena Specht, Ane Yde Schmidt, Finn Cilius Nielsen, Christian von Buchwald Source Type: research