Prognostic and clinicopathological significance of cyclin D1 expression in oral squamous cell carcinoma: A systematic review and meta-analysis

Oral cancer has a worldwide incidence of 300,400 cases and is responsible for 145,400 deaths a year (GLOBOCAN, IARC, WHO) [1]. Oral squamous cell carcinoma (OSCC) represents around 90% of malignant oral neoplasms [2] and has a 5-year survival rate of 50 –60% [2,3]. Prediction of the prognosis is of major importance and is usually based on the Tumor Node Metastasis (TNM) staging system, with N+ status and the presence of extracapsular spread predicting a worse prognosis [4,5]. The prognostic value of molecular biomarkers has attracted considerable research interest [6,7], and evidence has accumulated on a key role for cyclin D1 (CD1) in oral oncogenesis [8].
Source: Oral Oncology - Category: Cancer & Oncology Authors: Tags: Review Source Type: research