cAMP/PKA-induced filamin A (FLNA) phosphorylation inhibits SST2 signal transduction in GH-secreting pituitary tumor cells

An efficient intracellular response to somatostatin analogs (SSA) in pituitary tumors requires filamin A (FLNA). Since cAMP pathway plays an important role in GH-secreting pituitary tumors pathogenesis and FLNA is phosphorylated by PKA on S2152, aim of this study was to investigate in tumoral somatotrophs the impact of cAMP pathway activation and SSA stimulation on FLNA phosphorylation and the consequences on SST2 function.We found a PKA-mediated increase (2-fold) and SST2 agonist-induced decrease (-50%) of FLNA phosphorylation in GH3, GH4C1 and primary somatotroph tumor cells.

Source: Cancer Letters - August 8, 2018 Category: Cancer & Oncology Authors: E. Peverelli, E. Giardino, F. Mangili, D. Treppiedi, R. Catalano, E. Ferrante, E. Sala, M. Locatelli, A.G. Lania, M. Arosio, A. Spada, G. Mantovani Tags: Original Articles Source Type: research