NEW CONCEPTS IN FOLLICULAR LYMPHOMA BIOLOGY: FROM BCL2 TO EPIGENETIC REGULATORS AND NON-CODING RNAs

The molecular pathogenesis of follicular lymphoma (FL) was partially revealed three decades ago, with the discovery of the translocation that brought BCL2 under the influence of immunoglobulin heavy chain enhancers in a vast majority of cases. Despite the importance of these seminal observations, it has become increasingly clear that additional genetic alterations need to occur to trigger neoplastic transformation and disease progression. The evolution of FL involves developmental arrest and disruption of the normal function of one or more of epigenetic regulators including KMT2D/MLL2, EZH2, CBP/CREBBP, p300/EP300, and HIST1H1 in>95% of cases.
Source: Seminars in Oncology - Category: Cancer & Oncology Authors: Source Type: research