Pharmacogenomics, Precision Medicine, and Implications on Anesthesia Care

Publication date: Available online 6 August 2018Source: Best Practice & Research Clinical AnaesthesiologyAuthor(s): Alan D. Kaye, Thomas Mahakian, Aaron J. Kaye, Andrew A. Pham, Brendon M. Hart, Sonja Gennuso, Elyse M. Cornett, Rodney Gabriel, Richard D. UrmanAbstractThe study of how individual genetic differences known as polymorphisms change the pharmacokinetics and pharmacodynamics of drugs is pharmacogenomics. As the field of pharmacogenetics grows and continues to identify genetic polymorphisms, it is promising that the unmet need in this patient population may soon be addressed with personalized drug therapy based on the patient’s genetic composition. Although encouraging, pharmacogenomic testing is underutilized in the United States secondary to refusal of insurance companies to cover costs.This manuscript describes the current state of precision medicine as it relates to perioperative care and how preoperative genomic analysis can help improve patient outcomes. This investigation also outlines future directions in this important and evolving field.
Source: Best Practice and Research Clinical Anaesthesiology - Category: Anesthesiology Source Type: research