A case of intoxication with a mixture of synthetic cannabinoids EAM-2201, AB-PINACA and AB-FUBINACA, and a synthetic cathinone α-PVP

New psychoactive substances (NPS), such as synthetic cannabinoids and cathinones, are mostly used without the knowledge of their potential toxicities and pharmacokinetic properties, and hence many fatalities have been reported. After the application via inhalation of JWH-018 at 50 μg/kg, its serum concentration reached to the maximum 5 min post-smoking and rapidly dropped to values below 10 % of the maximum concentration within 3 h [1]. The rapid degradation may be one of the reasons that make the estimation of fatal serum/blood concentrations of NPS quite difficult.

Source: Legal Medicine - August 6, 2018 Category: Forensic Medicine Authors: Itaru Yamagishi, Kayoko Minakata, Hideki Nozawa, Koutaro Hasegawa, Masako Suzuki, Takuya Kitamoto, Osamu Suzuki, Kanako Watanabe Source Type: research