Evaluation of the efficacy of the 4 tests (p16 immunochemistry, polymerase chain reaction, DNA, and RNA in situ hybridization) to evaluate a human papillomavirus infection in head and neck cancers: a cohort of 348 French squamous cell carcinomas

In this study, using 348 head and neck SCCs (126 OP SCCs and 222 non-OP SCCs), we evaluated diagnostic performances of different HPV tests in OP and non-OP SCCs: polymerase chain reaction, p16 immunostaining, in situ hybridization targeting DNA (DNA-CISH) and RNA (RNA-CISH), combined p16 + DNA-CISH, and combined p16 + RNA-CISH.

Source: Human Pathology - April 20, 2018 Category: Pathology Authors: J érémy Augustin, Sophie Outh-Gauer, Marion Mandavit, Cassandre Gasne, Ophélie Grard, Thomas Denize, Marine Nervo, Haïtham Mirghani, Ollivier Laccourreye, Pierre Bonfils, Patrick Bruneval, David Veyer, Hélène Péré, Eric Tartour, Cécile Badoual Tags: Original contribution Source Type: research