First report of extensively-drug-resistant Proteus mirabilis isolate carrying plasmid-mediated blaNDM-1 in a Tunisian intensive care unit

The rapid emergence of antibiotic resistance among Gram-negative bacilli is a serious threat to the management of infectious diseases. β-lactam antibiotics are the most commonly used antimicrobials for empirical therapy. Production of β-lactamases is one of the strategies adopted by bacteria to develop resistance to the β-lactam class of antibiotics [1]. Proteus mirabilis is an emerging cause of nosocomial infections, particular ly of wounds and the urinary tract. The infections caused by this enterobacterial species are difficult to treat because of acquisition of various resistance mechanisms, such as extended-spectrum β-lactamases (ESBLs) and AmpC β-lactamases [2].
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Source Type: research