The effect of quinine in two bottle choice procedures in C57BL6 mice: opioid preference, somatic withdrawal, and pharmacokinetic outcomes

Opioid abuse remains a persistent public health concern in the United States, resulting in over 33,000 deaths in 2015 alone (Rudd et al., 2016). From 1999 to 2015, the number of overdose deaths attributable to prescription opioids has quadrupled (Center for Disease Control, 2017), highlighting prescribed analgesics as a substantial contributing factor to the epidemic. Similar to heroin, prescription opioids possess unwanted effects in addition to their therapeutic properties, notably abuse liability (Jimenez et al., 2017).
Source: Drug and Alcohol Dependence - Category: Addiction Authors: Tags: Full length article Source Type: research