A wobbly road to drug resistance in melanoma: tRNA-modifying enzymes in translation reprogramming

Alterations in transcript-specific translation are emerging as a driver of cellular transformation and cancer etiology. A new study provides evidence for enhanced codon-dependent translation of hypoxia-inducible factor 1α in promoting glycolytic metabolism and drug resistance in melanoma cells. This specialized translation reprogramming relies, in part, on mTORC2-mediated phosphorylation of enzymes modifying the wobble position of the transfer RNA anticodon.
Source: EMBO Journal - Category: Molecular Biology Authors: Tags: Cancer, Molecular Biology of Disease News [amp ] Views Source Type: research