Clock genes polymorphisms in male bipolar patients with comorbid alcohol abuse

Statistics show that 65% of bipolar disorder (BD) patients have one psychiatric comorbidity, 42% have two and 24% - three or more (McElroy et al., 2001). What is more, 45% of BD patients have co-morbid alcohol abuse/dependence (AAD) (Farren et al., 2012). Co-transmission of AAD in families has been reported for both disorders (BD and AAD) (Maier and Merikangas, 1996). Adoption studies revealed that substance abuse and BD was more common in biological relatives than in adoptive relatives, what confirms the genetic contribution (Ingraham and Wender, 1992).

Source: Journal of Affective Disorders - August 1, 2018 Category: Neurology Authors: Ewa Banach, Joanna Pawlak, Pawel Kapelski, Aleksandra Szczepankiewicz, Aleksandra Rajewska-Rager, Maria Skibinska, Piotr Czerski, Joanna Hauser, Monika Dmitrzak-Weglarz Tags: Research paper Source Type: research