Characterisation of a class 1 integron associated with the formation of quadruple blaGES-5 cassettes from an IncP-1 β group plasmid in Pseudomonas aeruginosa

Nosocomial infections caused by carbapenem-resistant Pseudomonas aeruginosa are one of the most common challenges for antimicrobial therapy. Resistance to carbapenems in P. aeruginosa can be attributed to a multitude of intrinsic mechanisms, including various efflux pumps, loss of the porin OprD, and increased AmpC β-lactamase expression [1,2]. In addition to intrinsic mechanisms, acquired mechanisms of resistance, such as metallo-β-lactamase and extended-spectrum β-lactamase production, have facilitated the emergence of carbapenem-resistant isolates, which has resulted in limited treatment options during r ecent decades [3].

Source: International Journal of Antimicrobial Agents - July 15, 2018 Category: Drugs & Pharmacology Authors: Teng Xu, Jian Wang, Jianchao Ying, Tingyuan Zhu, Yabo Liu, Lei Xu, Pingping Li, Peizhen Li, Jun Ying, Kewei Li, Huiguang Yi, Junwan Lu, Yunliang Hu, Tieli Zhou, Qiyu Bao Source Type: research