A Prospective Assessment of Periprosthetic Bone Mineral Density and Osteoimmunological Biomarkers Variations After Total Knee Replacement Surgery

Aseptic loosening is a major cause of premature failure of total knee replacement (TKR). Variations in periprosthetic bone mineral density (BMD) and osteoimmunological biomarkers levels could help to quantify prosthesis osteointegration and predict early aseptic loosening. The gene expression of 5 selected osteoimmunological biomarkers was evaluated in tibial plateau bone biopsies by real-time polymerase chain reaction and changes in their serum levels after TKR were prospectively evaluated with enzyme-linked immunosorbent assay for 1 yr after surgery.

Source: Journal of Clinical Densitometry - July 30, 2018 Category: Radiology Authors: Davide Cucchi, Alessandra Menon, Emanuela Galliera, Carmelo Messina, Beatrice Zanini, Monica Gioia Marazzi, Luca Massaccesi, Riccardo Compagnoni, Massimiliano M. Corsi Romanelli, Pietro Randelli Source Type: research