A detailed guide to lipid therapy in intestinal failure

Ninety years ago, the husband-and-wife team of George and Mildred Burr sought to better understand a possible new nutritional deficiency syndrome they had observed in rats consuming a “basal diet of the greatest simplicity.”1 Fed only purified casein, sucrose, electrolytes, and micronutrients, these lipid-restricted rats developed “an abnormal, scaly condition of the skin” after two months’ time. Symptoms progressed thereafter to include tails that became inflamed and s wollen, heavily scaled with ridges and superficial hemorrhages; copious dandruff on their backs; swollen feet with open sores; and a “caudal necrosis” involving hair loss and the appearance of sores on the back, neck, and face.
Source: Seminars in Pediatric Surgery - Category: Pediatrics Authors: Source Type: research