Lifetime affective problems and later-life cognitive state: over 50 years of follow-up in a British Birth Cohort Study

Many studies have demonstrated an association between depression and anxiety – affective symptoms - and subsequent cognitive impairment and dementia (Cherbuin et al., 2015; da Silva et al., 2013; Gulpers et al., 2016; John et al., 2018; Jorm, 2001; Ownby et al., 2006; Stella et al., 2014). The severity, frequency and onset of symptoms are thought to be important features i n establishing the nature of these associations (Bennett and Thomas, 2014; Byers and Yaffe, 2011; da Silva et al., 2013; Kaup et al., 2016; Köhler et al., 2010; Richards et al., 2014; Singh-Manoux et al., 2017), and feasibly affect cognitive function before dementia onset (Brailean et al., 2008; Bu tters et al., 2008; Luppa et al., 2013), perhaps through hippocampal atrophy (MacQueen and Frodl, 2011; McKinnon et al., 2009); although findings for cognitive decline are more inconsistent (Brailean et al., 2017).

Source: Journal of Affective Disorders - July 30, 2018 Category: Neurology Authors: Sarah-Naomi James, Daniel Davis, Celia O'Hare, Nikhil Sharma, Amber John, Darya Gaysina, Rebecca Hardy, Diana Kuh, Marcus Richards Tags: Research paper Source Type: research