Notch1 activation enhances proliferation via activation of cdc2 and delays differentiation of myeloid progenitors

The Notch signaling pathway is evolutionally conserved and has crucial roles in the control of proliferation, differentiation, apoptosis, and fate decision in numerous cell types [1,2]. The mammalian Notch family consists of four highly conserved transmembrane receptors (Notch 1, 2, 3, and 4), which can interact with five Notch ligands (Jagged 1 and 2, Delta-like 1, 3, and 4). When activated by ligand binding, the Notch receptor is cleaved, and its intracellular domain (ICN) translocates to the nucleus [3].

Source: Leukemia Research - July 30, 2018 Category: Hematology Authors: Makoto Nakamura, Lizi Wu, James D. Griffin, Satoru Kojika, Kumiko Goi, Takeshi Inukai, Kanji Sugita Source Type: research